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Takatoshi Iijima Associate Professor


Yoko Hanno-Iijima, Masami Tanaka, Takatoshi Iijima. (T.I. is a corresponding author) Activity-dependent bidirectional regulation of GAD expression in homeostatic fashion Is mediated by BDNF-dependent and independent pathways. PLoS ONE 10(8): e0134296 (2015)
Takatoshi Iijima, Yoko Hanno-Iijima, Harald Witte and Peter Scheiffele.
Neuronal cell-type specific alternative splicing is regulated by the KH-domain protein SLM1. Journal of Cell Biology 204:331-342(2014)
Peter Scheiffele and Takatoshi Iijima.
Choreographing the Axo-Dendritic Dance. Developmental Cell 23: 923-924 (2012)
Takatoshi Iijima, Karen Wu, Harald Witte, Yoko Hanno-Iijima, Timo Glatter, Stephane Richard and Peter Scheiffele.
SAM68 regulates neuronal activity-dependent alternative splicing of Neurexin-1. Cell 147: 1601-1615 (2011)
(Featured as a "Must Read" paper on Faculty of 1000 Biology)
Peter Scheiffele, Takatoshi Iijima, Harald Witte, Karen Wu, Fatiha Boukhtouche, Anna Kalinovsky.
Molecular mechanisms of synaptic differentiation and selective synapse assembly. International Journal of Developmental Neuroscience 28: 639-640. (2010)
Takatoshi Iijima, Eriko Miura, Masahiko Watanabe and Michisuke Yuzaki.
Distinct expression of C1q-like family mRNAs in mouse brain and biochemical characterization of their encoded proteins. European Journal of Neuroscience 31: 1606-1615 (2010)
(T.I. and E.M. equally contribute to this work)
Takatoshi Iijima, Kyoichi Emi and Michisuke Yuzaki.
Activity-dependent repression of Cbln1 expression: Mechanism for developmental and homeostatic regulation of synapses in cerebellum. The Journal of Neuroscience 29: 5425-5435 (2009)
Keiko Matsuda, Tetsuro Kondo, Takatoshi Iijima, Shinji Matsuda, Masahiko Watanabe and Michisuke Yuzaki.
Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum. European Journal of Neuroscience 29: 707-717 (2009)
Aya Ito-Ishida, Eriko Miura, Kyoichi Emi, Keiko Matsuda, Takatoshi Iijima, Tetsuro Kondo, Masahiko Watanabe and Michisuke Yuzaki.
Cbln1 regulates rapid Formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo. The Journal of Neuroscience 28: 5920-5930 (2008)
Takatoshi Iijima, Hiroo Ogura, Kanako Takatsuki, Shigenori Kawahara, Kenichiro Wakabayashi, Daisuke Nakayama, Masato Fujioka, Yuki Kimura, Alan Bernstein, Hirotaka James Okano, Yutaka Kirino and Hideyuki Okano.
Impaired motor functions in mice lacking the RNA-binding protein Hzf. Neuroscience Research. 58: 183-189 (2007)
Takatoshi Iijima, Eriko Miura, Keiko Matsuda, Yuichi Kamekawa, Masahiko Watanabe and Michisuke Yuzaki.
Characterization of a transneuronal cytokine family Cbln - Regulation of secretion by heteromeric assembly. European Journal of Neuroscience. 25: 1049-1057 (2007)
Eriko Miura, Takatoshi Iijima, Michisuke Yuzaki and Masahiko Watanabe.
Distinct expression of Cbln family in developing and adult brain. European Journal of Neuroscience. 24: 750-760 (2006)
Takatoshi Iijima, Takao Imai, Hirotaka James Okano, Yuki Kimura, Alan Bernstein, Michisuke Yuzaki and Hideyuki Okano.
Hzf protein regulates dendritic localization and BDNF-induced translation of type1 Inositol 1,4,5-trisphosphate receptor mRNA. Proceedings of the National Academy Sciences of the United States of America. 102: 17190-17195 (2005)
Hiroshi Mori, Shin-ichiro Sakakibara, Takao Imai, Yuki Nakamura, Takatoshi Iijima, Akira Suzuki, Yoshihiro Yuasa, Masatoshi Takeda and Hideyuki Okano. Expression of mouse igf2 mRNA-binding protein 3 and its implications for the developing central nervous system. Journal of Neuroscience Research 64: 132-143 (2001)

Presentations (Seminars/ Symposiums/ Lectures)

10 -11.10.2014
Presentation on Molecular analysis of autism related synaptic phenotypes using in-vivo and in-vitro VPA models at 10th workshop by the institute of medical sciences
Presentation on 「 RNA-based Program Underlying Neuronal Differentiation and Plasticity 」 at in seminar hosted by Prof. Taisuke Tomita in Department of Pharmaceutical Science, Tokyo University (at Tokyo)
Presentation on “ RNA-based mechanisms that underlying neuronal differentiation and plasticity” in seminar hosted by Prof. Toshifumi Inada in Department of Pharmaceutical Science, Tohoku University (at Sendai)
Presentation on “ RNA-based mechanisms that underlying neuronal differentiation and plasticity” in seminar hosted by Prof. Masatoshi Hagiwara in Graduate School of Medicine, Kyoto University (at Kyoto).
Oral presentation on “Molecular mechanism underlying synaptic specificity and plasticity - Dynamic regulation of alternative pre-mRNA splicing of Neurexins” in Neuro2013 (at Kyoto)
Presentation on “Mechanisms Underlying Neuronal Differentiation and Synaptic Plasticity: Dynamic Regulation of Alternative pre-mRNA Splicing in Neurons” in invited symposium of Tokyo RNA Club (at Tokyo)
Oral presentation on “Molecular mechanism underlying synaptic specificity and plasticity - Dynamic regulation of alternative pre-mRNA splicing of Neurexins” in Workshop in annual meeting for the Molecular Biology Society of Japan


2015‐2017 Grant-in-Aid for Scientific Research (B) delegate
2015-2017 Grant-in –Aid Fund for Challenging Exploratory Research delegate
2014 The Mitsubishi Foundation Research Grants in the Natural Sciences
2014-2016 The Takeda Science Foundation Research Grant for Medicine
2014-2015 Yamada Science Foundation Research support
2008 Grant-in-Aid for Young Scientists (B)
2006 Grant-in-Aid for Young Scientists (B)