Kamiya et al. Invited Presentation on "Induction of hepatic stem/progenitor cells derived from human iPS cells" (at Tokyo) in the 87th Annual Meeting of　Japan Tissue Culture Association

Ito K, Yanagida A, Okada K, Yamazaki Y, Nakauchi H, Kamiya A*. Mesenchymal progenitor cells in mouse fetal liver regulate differentiation and proliferation of hepatoblasts. Liver Int. 2013 in press. (*Corresponding Author)

Yanagida A, Ito K, Chikada H, Nakauchi H, Kamiya A*. An in vitro expansion system for generation of human iPS cell-derived hepatic progenitor-like cells exhibiting a bipotent differentiation potential. PLoS One, 8, e67541, 2013. (*Corresponding Author)

Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fijuki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M. Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells. Hepatology, 57, 2502-13, 2013.

Oikawa T, Kamiya A*, Zeniya M, Chikada H, Hyuck AD, Yamazaki Y, Wauthier E, Tajiri H, Miller LD, Wang XW, Reid LM*, Nakauchi H*. Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers. Hepatology 57, 1469-83, 2013. (*Corresponding Authors)

Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Masaki H, Kobayashi T, Yamazaki S, Nakauchi H. Development of an All-in-One Inducible Lentiviral Vector for Gene Specific Analysis of Reprogramming. PLoS One. 7, e41007, 2012

Sekine K, Takebe T, Suzuki Y, Kamiya A, Nakauchi H, Taniguchi H. Highly efficient generation of definitive endoderm lineage from human induced pluripotent stem cells. Transplant Proc. 44, 1127-9, 2012.

Ito H, Kamiya A*, Ito K, Yanagida A, Okada K, Nakauchi H*. In vitro expansion and functional recovery of mature hepatocytes from mouse adult livers. Liver Int. 32, 592-601, 2012.
(*Corresponding Authors)

Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R. In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. Blood. 119, e45-56, 2012.

Okada K, Kamiya A*, Ito K, Yanagida A, Ito H, Kondou H, Nishina H, Nakauchi H*. Prospective isolation and characterization of bi-potent progenitor cells in early mouse liver development. Stem Cells Dev. 21, 1124-33, 2012.
(*Corresponding Authors)

Onozuka I, Kakinuma S, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, Watanabe T, Funaoka Y, Ueyama M, Nakagawa M, Koshikawa N, Seiki M, Nakauchi H, Watanabe M. Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice. Biochem Biophys Res Commun. 406, 134-40, 2011.

Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A. Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and independent manners. Hepatology 52, 1111-1123, 2010.

Kamiya A*, Kakinuma S, Yamazaki Y, Nakauchi H*. Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mice. Gastroenterology 137, 1114-1126, 2009.
(*Corresponding Authors)

Kakinuma S, Ohta H, Kamiya A, Yamazaki Y, Oikawa T, Okada K, Nakauchi H. Analyses of cell surface molecules on hepatic stem/progenitor cells in mouse fetal liver. J Hepatol. 51, 127-138, 2009.

Oikawa T, Kamiya A*, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H*. Sall4 Regulates Cell Fate Decision in Fetal Hepatic Stem/Progenitor Cells. Gastroenterology 136, 1000-1011, 2009.
(*Corresponding Authors)

Kamiya A*, Kakinuma S, Onodera M, Miyajima A, Nakauchi H*. Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts. Hepatology 48, 252-64, 2008.
(*Corresponding Authors)

Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H. The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood 110, 3637-47, 2007.

Barbier O, Girard H, Inoue Y, Duez H, Villeneuve L, Kamiya A, Fruchart JC, Guillemette C, Gonzalez FJ and Staels B. Hepatic expression of the UGT1A9 is governed by HNF4alpha. Mol. Pharm. 67, 241-249, 2005.

Kamiya A, Inoue Y, Kodama T and Gonzalez FJ. Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett. 578, 63-68, 2004.

Kamiya A and Gonzalez FJ. Tumor necrosis factor-a regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices. Hepatology 40, 527-536, 2004.

Kamiya A, Inoue Y and Gonzalez FJ. Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. Hepatology 37, 1375-1384, 2003.

Anzai H, Kamiya A, Shirato H, Takeuchi T and Miyajima A. Impaired differentiation of fetal hepatocytes in homozygous jumonji mice, Mech. Dev. 120, 791-800, 2003.

Matsui T, Kinoshita T, Morikawa Y, Tohya K, Katsuki M, Ito Y, Kamiya A and Miyajima A. K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development. EMBO J. 21, 1021-1030, 2002.

Kamiya A, Kojima N, Kinoshita T, Sakai Y and Miyajima A. Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: Induction of tryptophan oxygenase. Hepatology 35, 1351-1359, 2002.

Kamiya A, Kinoshita T and Miyajima A. Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways. FEBS Lett. 492, 90-94, 2001.

Ito Y, Matsui T, Kamiya A, Kinoshita T and Miyajima A. Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and ras pathways during hepatic development. Hepatology 32, 1370-1376, 2000.

Kinoshita T, Sekiguchi T, Xu MJ, Ito Y, Kamiya A, Tsuji K, Nakahata T and Miyajima A. Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc. Natl. Acad. Sci. USA. 96, 7265-7270, 1999.

Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, Nakashima K, Taga T, Yoshida K, Kishimoto T and Miyajima A. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 18, 2127-2136, 1999.

Kamiya A, Miyajima A.　Mice with artificial human liver. Hepatology. 55, 974-976, 2012.

Chiba T, Kamiya A, Yokosuka O, Iwama A. Cancer stem cell in hepatocellular carcinoma: Recent progress and perspective. Cancer Lett. 286, 145-153, 2009.

Kamiya A, Gonzalez FJ and Nakauchi H. Identification and differentiation of hepatic stem cells during liver development. Front Biosci. 11, 1302-1310, 2006.

Miyajima A, Kinoshita T, Tanaka M, Kamiya A, Mukouyama Y, Hara T. Role of Oncostatin M in hematopoiesis and liver development. Cytokine Growth Factor Rev. 11, 177-183, 2000.

Kamiya A, Nakauchi H.　Enrichment and clonal culture of hepatic stem/progenitor cells during mouse liver development.
In Methods Mol Biol. “Epithelial Cell Culture Protocols.” (edited by Randell SH and Fulcher ML.) 2013;945:273-86. doi: 10.1007/978-1-62703-125-7_16

Poster Presentation on “Establishment of culture system for analyses of biliary tract diseases using pluripotent stem cells” (at Sapporo) in 1st International Meeting for Epithelial Tubulology.

Chikada et al. Poster Presentation on " REGULATION OF CYTOCHROME p450 3A11 EXPRESSION IN MOUSE HEPATIC PROGENITOR CELLS BY BCL-6" (at Boston, USA) in the 11th Annual Meeting of International Society for Stem Cell Research

Oral Presentation on “Generating of bi-potent hepatic stem/progenitor-like cells derived from human iPS cells.” (at Tokyo) in The 49th Annual Meeting of the Japan Society of Hepatology.

Poster Presentation on “Bile ductule formation using purified hepatic stem/progenitor-like cells derived from human iPS cells.” (at Tokyo) in Winter symposium of Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas.

Invited Presentation on “An in vitro expansion system in generating purified hepatic stem/progenitor-like cells derived from human iPS cells.” (at Fukuoka) in Workshop of The 35th Annual Meeting of the Molecular Biology Society of Japan.

Invited Presentation on “Establishment of cell therapies uging hepatic stem/progenitor cells derived from human iPS cells” (at Hiratsuka) in the 9th Annual Meeting of The Japanese Society for the Research of Hepatic cells.

Oral Presentation on “Mechanism regulating proliferation of hepatic stem/progenitor cells by MEK-ERK signal pathway” (at Sapporo) in the 9th Annual Meeting of The Japanese Society for the Research of Hepatic cells.

Invited Presentation of luncheon seminar on “Proliferation of fetal hepatoblasts regulated by the MEK-MAPK signal pathway” (at Yokohama) in the 11th Annual Meeting of the Japanese Society of Regenerative Medicine.

Poster Presentation on " MEK activity regulates stem/progenitoer potential of fetal hepatoblasts through induction of cell cycle arrest." (at Yokohama) in the 10th Annual Meeting of International Society for Stem Cell Research.

Invited Presentation on “Stem cell system in liver development and regeneration” (at Sendai) in Global COE "Network Medicine" Seminar in Tohoku University.

Oral Presentation on “Proliferation of fetal hepatoblasts regulated by the MEK-MAPK signal pathway” (at Kanazawa) in The 48th Annual Meeting of the Japan Society of Hepatology.

Invited Presentation on “Establishment of cell therapies uging hepatic stem/progenitor cells derived from human iPS cells” (at Tokyo) in The 8th "Frontier in Liver immunology and virus".

2013-2014 Grant-in-Aid on Challenging Exploratory Research

2012-2013 Grant-in-Aid on Innovative Areas

2011-2013 Grants-in-Aid for Young Scientists (A)

2011-2013 Health Labour Sciences Research Grants