The first Kotani Lab-led research paper since its start has been accepted by BLOOD.

Toyotaka Kawamata+, Jun Lu+, Tadayuki Sato+, Masafumi Tanaka, Hitoshi Nagaoka, Yasutoshi Agata, Takae Toyoshima, Kazuaki Yokoyama, Naoki Oyaizu, Naoya Nakamura, Kiyoshi Ando, Arinobu Tojo*, and Ai Kotani*. +equally contributed *corresponding author.
Imatinib mesylate directly impairs class switch recombination through downregulation of AID.
Blood. 2012 Mar 29;119(13):3123-7.

Seo S, Nakamoto T, Takeshita M, Lu J, Sato T, Suzuki T, Kamikubo Y, Ichikawa M, Noda M, Ogawa S, Honda H, Oda H, Kurokawa M.
Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl. Cancer Sci. 2011 Aug 16.

Harnprasopwat R+, Lodish HF,, Ha D, Toyoshima T, Tojo A and Kotani A*+
*correspondence author + equally contributed.
Alteration of processing induced by a single nucleotide polymorphism in pri-miR-126
Biochemical and Biophysical Research Communications 2010 Aug 20;399(2):117-22.

Kotani A, Ha D, Schotte D, den Boer ML, Armstrong SA, and Lodish HF
A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 Acute Lymphocytic Leukemia cells.
Cell Cycle 2010 Mar 18;9(6)

Kotani A, Ha D, Hsieh J, Rao R, Schotte D,den Boer ML, Armstrong SA, and Lodish HF
miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 Acute Lymphocytic Leukemia cells and exerts synergistic effects with miR-221 . Blood. 2009 Nov 5;114(19):4169-78.

Kotani A, Hori T, Fujita T, Kambe N, Matsumura Y., Ishikawa T, Miyachi Y, Nagai K, Tanaka Y, and Uchiyama T
Involvement of OX40 ligand+ mast cells in chronic GVHD after allogeneic hematopoietic　stem cell transplantation. Bone Marrow Transplant.39(6):373-5, 2007

Kotani A, Kakazu N, Tsuruyama T, Okazaki IM, Muramatsu M, Kinoshita K, Nagaoka H, Yabe D and Honjo T
AID promotes B cell lymphomagenesis in Emu-cmyc Transgenic mice.
Proc Natl Acad Sci U S A. 104;1616-20. 2007

Kotani A, Okazaki IM, Muramatsu M, Kinoshita K, Begum NA, Nakajima T, Saito H and Honjo T.
A target selection of SHM is regulated similarly between T and B cells upon AID expression. Proc Natl Acad Sci U S A.102;4506-45611,2005

Kotani A, Takahashi A, Koga H, Morita R, Fukuyama H, Ichinohe T, Ishikawa T, Hori T, and Uchiyama T.
Myasthenia gravis after bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40+CD4+T cells.
Eur. J. Haematol. 69:318-320, 2002.

Kotani A, Hori T, Matsumura Y, and Uchiyama T. Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC chemokine RANTES/CCL5. Immunol. Lett. 84:1-7,2002.

Kotani A, Ishikawa T, Matsumura Y, Ichinohe T, Ohno H, Hori T, and Uchiyama T:
Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation.
Blood 98(10):3162-3164, 2001.

Honjo T, Kobayashi M, Begum N, Kotani A, Sabouri S, Nagaoka H.
The AID Dilemma: Infection, or Cancer? Adv Cancer Res. 2012;113:1-44.

Kotani A＊+, Harnprasopwat R+ Kawamata T, Toyoshima T, and Tojo A
*correspondence author + equally contributed.
miRNAs in normal and malignant B cells
International Journal of Hematology 2010 Sep;92(2):255-61

Okazaki IM, Kotani A and Honjo T
Role of AID in Tumorigenesis
Advances in Immunology; 94:245-73. 2007

Jun Lu+, Bidisha Chanda+ and Ai Kotani+*.
*corresponding author +equally contributed.
Epstein-Barr Virus-Encoded miRNAs in Epstein-Barr Virus-Related Malignancy.
Hematology - Science and Practice 2012.

Kazuaki Yokoyama Oral Presentations
Ai Kotani Poster Presentations

7th-11th Dec 2012
American Society of Hemaology Atlanta

Kotani: Invited lecture on “miRNA in hematological malignancy: promising therapeutic target” at the 13th Pharmaco-Hematology Symposium by the Pharmaceutical Society of Japan, Division of Pharma-Biology (Nagai Memorial Hall at Shibuya, Tokyo).

Kotani: Poster session at Keystone Symposia’s 2012 Meeting on “Mutations, Malignancy and Memory - Antibodies and Immunity” (at Boston, Massachusetts).

Kotani: Seminar on “Secretary miRNA in EBV related lymphoma” at Frontier Research Center for Post-genome Science and Technology, Hokkaido University (at Sapporo, Hokkaido).

Lu J.: Poster session at Keystone Symposia’s 2012 Meeting on “Gene Silencing by Small RNAs” (at Vancouver, British Columbia).

Research progress report at the Tokai University’s 2nd Symposium for Tenure Track Program (at Kasumigaseki, Tokyo).

International Myeloma Foundation Award Presentation at the American Society of Hematology (at San Diego, USA).

Presentation at the Myeloma Seminar 2011 by the International Myeloma Foundation Japan (at Shinagawa, Tokyo).

Presentations at the 73rd Annual Meeting of the JSH 2011 (at Nagoya).

Presentation at the 70th Annual Meeting of JCA 2011 (at Nagoya).

Presentation at Meeting of "Cell Fate" (at Karuizawa).

Lecture at Kitazato University School of Science (at Sagamihara).

Presentations at JARI 2011 (at Hiroshima).

Presentations at "Meet the hematologist" (at Kyoto).

Kazuki Okuyama
Awarded by Tadamitsu Kishimoto International Travel Award

2011 - 2012 Health Labour Sciences Research Grants

2011 - 2012 Grants-in-Aid for Scientific Research on Innovative Areas

2010 - 2011 Grants-in-Aid for Young Scientists (B)