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Shigeaki Inoue Assistant Professor

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Invited Lecture [06.10.2012]
Invited lecture on “IMPAIRED INNATE AND ADAPTIVE IMMUNITY OF ACCELERATED-AGING KLOTHO MICE WITH SEPSIS” at the 7th Congress of International Federation of Shock Societies and the 35th Annual Conference on Shock (Miami, FL. US).
Session: Plenary Symposium II: The Influence of Predisposing Conditions on the Pathophysiology of Injury and Sepsis (Session Times: 9:00AM - 11:30AM)

Publications

Inoue S, Bo L, Bian J, Unsinger J, Chang K, Hotchkiss RS. Dose dependent effect of anti-CTLA-4 on survival in sepsis. Shock ;36:38-44, 2011
Suzuki S, Inokuchi S, Takazawa K, Umezawa K, Saito T, Kidokoro M, Tanaka M, Matsuzawa, H, Inoue S, Tuchiya I, Ando K. Introduction of human β-defensin-3 into cultured human keratinocytes and fibroblasts by infection of a recombinant adenovirus vector. Burns ;37:109-16, 2011
Inoue S, Unsinger J, Davis CG, Muenzer JT, Ferguson TA, Chang K, Osborne DF,Clark AT, Cppersmith CM, McDunn JE, Hotchkiss RS. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol. 184:1401-1409, 2010
Brahmamdam P, Inoue S, Unsinger J, Chang KC, McDunn JE, Hotchkiss RS. Delayed administration of anti-PD-1 antibody reverses immne dysfunction and improves survival duing sepsis. J Leukoc Biol.;88:233-240, 2010
Inoue S, Kijima H, Kidokoro M, Tanaka M, Suzuki Y, Motojuku M, Inokuchi S. The effectiveness of basic fibroblast growth factor for cultured skin. J Burn Care Research ;30:514-519, 2009
Inoue S, Tsuji T, Morita S, Inokuchi S. Painless Acute Aortic Dissection, not Brain Infarction. Emerg Med J. ;26:423, 2009
Inoue S, Saito T, Miyazawa T, Mase H, Inokuchi S. A simple method for detecting fenitrothion, its metabolite 3-methyl-4-nitrophenol, and other organophosphorus pesticides in human urine by LC-MS. Forensic Toxicol. ;27:32-36, 2009
Inoue S, Saito T, Suzuki Y, Iizuka S, Takazawa K, Akieda K, Yamamoto I, Inokuchi S. Prognostic factors and toxicokinetics in acute fenitrothion self-poisoning requiring intensive care. Clin Toxicol (Phila). ;46:528-533, 2008
Inoue S, Saito T, Tsuji T, Tamura K, Ohama S, Morita S, Yamamoto I, Inokuchi S. Lactate as a prognostic factor in carbon monoxide poisoning: a case report. Am J Emerg Med. ;26:966.e1-3, 2008

Presentations (Seminars/ Symposiums/ Lectures)

03.20~23.2012
Poster Presentation “Impaired innate and adaptive immunity of accelerated-aged “Klotho” mice in sepsis”, “Decreased peripheral CD4+/CD8+ lymphocytes and poor prognosis in elderly sepsis” at the 32nd International Symposium on Intensive Care and Emergency Medicine (Brussels, Kingdom of Belgium).
03.02.2012
Oral Presentation “Aging of T cells and sepsis” at the 15th meeting of the institute of medical science in Tokai University (Isehara, Kanagawa).
02.29.2012
Poster Presentation “Immuno analysis of elderly patients in sepsis” and “Systematic review of accuracy of glucose measurement in critical care patients” at the 39th annual meeting of the Japanese society of intensive care medicine (Chiba).
12.19.2011
Research progress report at the Tokai University’s 2nd Symposium for Tenure Track Program (Kasumigaseki, Tokyo)
12.12.2011
Oral Presentation “Operations research and emergency medicine” at the meeting of service science of association of operations research (Bunkyo-ku, Tokyo).
12.08.2011
Oral Presentation “Immuno analysis of elderly sepsis patients” at the 18th annual meeting of Geka-shinshu to Cytokine Kenkyukai (Kanazawa, Ishikawa).
11.28.2011
Poster Presentation “Immuno analysis of septic Klotho mice” at the 40th annual meeting of the Japanese society for immunology (Chiba).
10.21.2011
Invited lecture “A novel therapeutic strategy for aged sepsis by T lymphocyte proliferator, IL-15” at the Septicaemia Seminar by the Technical Information Institute (Shinagawa, Tokyo).
10.20.2011
Chair “ICU 2” at the 39th Annual Meeting of the Japanese Association for Acute Medicine (Keio Plaza Hotel, Tokyo).
10.19.2011
Presentation at the 39th Annual Meeting of the Japanese Association for Acute Medicine (Keio Plaza Hotel, Tokyo).
07.04.2011
Invited lecture in English at Second Military Medical University-Shanghai (China).
06.29.2011
Invited lecture in English at Chinese Academy Dalian (China).
02.24.2011
Presentation at Pacifico Yokohama.

Grants

2011-2012 A-STEP program supported by Japan Science and Technology Agency
2011 Grants-in-Aid for Young Scientists (B)