Invited lecture on “Development of Nanobiomaterials for Biomedical Applications” at The 41th Summer Seminar in Tohoku Branch in The Society of Polymer Science, Japan (at Koriyama, Japan).
http://res.tagen.tohoku.ac.jp/~polymer/

Invited lecture on “Development of Polymer Nanosheets for Imaging interactions between Platelet and ligands” at FY2013 Meeting on Imaging for Young Researchers (at Tokyo University of Science, Chiba, Japan).
http://hikarijyuku.mad.buttobi.net/

Presentation on “Fabrication of Biodegradable Polymer Nanosheets with Various Size and Their Biomedical Applications” at The 62th Symposium on Macromolecules (at Kanazawa University Kakuma Campus, Kanazawa, Japan).
http://main.spsj.or.jp/tohron.html

Taguchi K, Ujihira H, Ogaki S, Watanabe H, Fujiyama A, Doi M, Okamura Y, Takeoka S, Ikeda Y, Handa M, Otagiri M and Maruyama T. Pharmacokinetic study of the structural components of adenosine diphosphate-encapsulated liposomes coated with fibrinogen γ-chain dodecapeptide as a synthetic platelet substitute. Drug Metab. Dispos. (2013) in press.

Okamura Y*, Kabata K, Kinoshita M, Miyazaki H, Saito A, Fujie T, Ohtsubo T, Saitoh D, and Takeoka S*. Fragmentation of poly(lactic acid) nanosheets and patchwork treatment for burn wounds. Adv. Mater. 25, 545-551 (2013). Highlighted by ChemistryViews (Wiley-VCH) and ワイリー・サイエンスカフェ (Wiley-Japan). *Corresponding Author

Tobimatsu H, Paragon A, Okamura Y, Takeoka S, Sudo R, Ikeda Y and Tanishita K. Drift and fluctuating motion of artificial platelets during the lateral transport and adhesion process near the wall. J. Biorheol.26, 11-20 (2013).

Okamura Y, Schmidt R, Raschke I, Hintiz M, Takeoka S, Egner A and Lang T. A few immobilized thrombins are sufficient for platelet spreading. Biophys. J. 100, 1855-1863 (2011). (Highlighted by Biophys. J.)

Aquino D, Schönle A, Geisler C, Middendorff CV, Wurm CA, Okamura Y, Lang T, Hell SW and Egner A. Two-color nanoscopy of three-dimensional volumes by 4Pi detection of stochastically switched fluorophores. Nat. Methods 8,353-359 (2011). (Highlighted by Nat. Methods)

Suzuki H, Okamura Y, Ikeda Y, Takeoka S and Handa M. Ultrastructural analysis of thrombin-induced interaction between human platelets and liposomes carrying fibrinogen γ-chain dodecapeptide as a synthetic platelet substitute. Thromb. Res.128, 552-559 (2011).

Yoshida H, Okamura Y, Watanabe N, Ikeda Y and Handa M. Shear-dependent suppression of platelet thrombus formation by phosphodiesterase 3 inhibition requires low levels of concomitant Gs-coupled receptor stimulation. Thromb. Haemost. 105, 487-495 (2011).

Okamura Y, Katsuno S, Suzuki H, Handa M, Ikeda Y and Takeoka S. Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane properties and their hemostatic effects as a platelet substitute. J. Control. Release 148, 373-379 (2010).

Okamura Y, Eto K, Maruyama H, Handa M, Ikeda Y and Takeoka S. Visualization of liposomes carrying fibrinogen γ-chain dodecapeptide accumulated to sites of vascular injury using computed tomography. Nanomedicine 6, 391-396 (2010).

Fujie T, Kinoshita M, Shono S, Saitoh A, Okamura Y, Saito D and Takeoka S. Sealing effect of a polysaccharide nanosheet for murine cecal puncture. Surgery 148, 48-58 (2010).

Okamura Y, Kabata K, Kinoshita M, Saito D and Takeoka S. Free-standing biodegradable poly(lactic acid) nanosheet for sealing operations in surgery. Adv. Mater. 21, 4388-4392 (2009). (Highlighted by “Chemistry World” in Royal Society of Chemistry)

Okamura Y, Fukui Y, Kabata K, Suzuki H, Handa M, Ikeda Y and Takeoka S. Novel platelet substitutes: disk-shaped biodegradable nanosheets and their enhanced effects on platelet aggregation. Bioconjug. Chem. 20, 1958-1965 (2009).

Okamura Y, Takeoka S, Eto K, Maekawa I, Fujie T, Maruyama H, Ikeda Y and Handa M. Development of fibrinogen γ-chain peptide-coated, adenosine-diphosphate-encapsulated liposomes as a synthetic platelet substitute. J. Thromb. Haemost. 7, 470-477 (2009).

Okamura Y, Goto T, Niwa D, Fukui Y, Otsuka M, Motohashi N, Osaka T and Takeoka S. Fabrication of free-standing albumin-nanosheets having heterosurface. J. Biomed. Mater. Res. A 89A, 233-241 (2009).

Fujie T, Okamura Y and Takeoka S. Selective surface modification of free-standing polysaccharide nanosheet with micro/nano-particles utilizing structural color. Colloids Surf. A 334, 28-33 (2009).

Fujie T, Matsutani N, Kinoshita M, Okamura Y, Saito A and Takeoka S. Adhesive, flexible and robust polysaccharide nanoseet integrated for tissue-defect repair. Adv. Funct. Mater. 19, 2560-2568 (2009). (Highlighted by Nat. Nanotech.)

Wada T, Okamura Y, Takeoka S, Sudo R, Ikeda Y and Tanishita K. Deformability and adhesion force of artificial platelets measured by atomic force microscopy. J. Biorheol. 23, 35-40 (2009).

Tsuji T, Takeoka S, Okamura Y, Sudo R, Ikeda Y and Tanishita K. Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells. J. Biorheol. 23, 29-34 (2009).

Ciofani G, Obata Y, Sato I, Okamura Y, Raffa V, Menciassi A, Dario P, Takeda N and Takeoka S. Realization, characterization and functionalization of lipidic wrapped carbon nanotubes. J. Nanoparticle. Res. 11, 477-484 (2009).

Kubota T, Fukuya Y, Hashimoto R, Kanda T, Suzuki H, Okamura Y, Nanki T, Miyasaka N and Umezawa K. Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome. Ann. N.Y. Acad. Sci. 1173, 137-145 (2009).

Okamura Y, Fujie T, Nogawa M, Maruyama H, Handa M, Ikeda Y and Takeoka S. Hemostatic effects of polymerized albumin particles carrying fibrinogen γ-chain dodecapeptide as platelet substitutes in severely thrombocytopenic rabbits. Transf. Med. 18, 1-9 (2008).

Okamura Y, Utsunomiya S, Suzuki H, Niwa D, Osaka T and Takeoka S. Fabrication of free-standing nanoparticle-fused nanosheets and their hetero-modification using sacrificial film. Colloids Surf. A 318, 184-190 (2008).

Okamura Y, Fujie T, Maruyama H, Handa M, Ikeda Y and Takeoka S. Prolonged hemostatic ability of poly(ethylene glycol)-modified polymerized albumin particles carrying fibrinogen γ-chain dodecapeptide. Transfusion 47, 1254-1262 (2007).

Fujie T, Okamura Y and Takeoka S. Ubiquitous transference of free-standing polysaccharide nanosheet in the development of a nano-adhesive plaster. Adv. Mater. 19, 3549-3553 (2007).

Okamura Y, Handa H, Suzuki H, Ikeda Y and Takeoka S. New strategy of platelet substitutes for enhancing platelet aggregation at high shear rates; cooperative effects of a mixed system of fibrinogen γ-chain dodecapeptide- or glycoprotein Ibα-conjugated latex beads under flow conditions. J. Artif. Organs 9, 251-258 (2006).

Okamura Y, Maekawa I, Teramura Y, Maruyama H, Handa H, Ikeda Y and Takeoka S. Hemostatic effects of phospholipid vesicles carrying fibrinogen γ-chain dodecapeptide in vitro and in vivo. Bioconjug. Chem. 16, 1589-1596 (2005).

Okamura Y, Takeoka S, Teramura Y, Maruyama H, Tsuchida E, Handa M and Ikeda Y. Hemostatic effects of fibrinogen γ-chain dodecapeptide-conjugated polymerized albumin particles in vitro and in vivo. Transfusion 45, 1221-1228 (2005).

Matsubara Y, Murata M, Hayashi T, Suzuki K, Okamura Y, Handa M, Ishihara H, Shibano T and Ikeda Y. Platelet glycoprotein Ibα polymorphisms affect the interaction with von Willebrand factor under flow conditions. Br. J. Haematol. 128, 533-539 (2005).

Okamura Y, Teramura Y, Takeoka Y, Tsuchida E, Suzuki H, Watanabe N, Handa M, and Ikeda Y. Development of fibrinogen γ-chain dodecapeptide-conjugated particles. Artificial Blood 11, 205-210 (2003).

Takeoka S, Okamura Y, Teramura Y, Watanabe N, Suzuki H, Tsuchida E, Handa M and Ikeda Y. Function of fibrinogen γ-chain dodecapeptide-conjugated latex beads under flow. Biochem. Biophys. Res. Commun. 312, 773-779 (2003).

Teramura Y, Okamura Y, Takeoka S, Kainoh M, Narumi H, Tsuchiyama H, Handa M, Ikeda Y and Tsuchida E. Hemostatic effects of polymerized albumin particles bearing rGPIa/IIa in thrombocytopenic mice. Biochem. Biophys. Res. Commun. 306, 256-260 (2003).

Takeoka S, Teramura Y, Okamura Y, Handa M, Ikeda Y and Tsuchida E. Rolling properties of rGPIbα-conjugated phospholipid vesicles with different membrane flexibility on the vWf surface under flow conditions. Biochem. Biophys. Res. Commun. 296, 765-770 (2002).

Takeoka S, Teramura Y, Okamura Y, Handa M, Ikeda Y and Tsuchida E. Fibrinogen-conjugated albumin polymers and their interaction with platelets under flow conditions. Biomacromolecules 2, 1192-1197 (2001).

Okamura Y and Lang T. Interactions between artificial surfaces and platelets. Int. Rev. Thromb. 8, 42-49 (2013).

Takeoka S, Fukui Y, Fujie T and Okamura Y. Novel Polymeric Nanosheets for Gerontic Applications. Gerontechnology 7, 220-224 (2008).

Takeoka S, Okamura Y, Fujie T and Fukui Y. Development of biodegradable nanosheets as nano-adhesive plaster. Pure Appl. Chem. 80, 2259-2271 (2008).

Fujie T, Okamura Y and Takeoka S. Fabrication, Properties and Biomedical Applications of Nanosheets. “Functional Polymer Films” (Editors: Prof. R.C. Advincula and Prof. W. Knoll), Wiely-VCH. 907-931(2011).

Oral Presentation on “Fragmentation of Biocompatible Polymer Nanosheets and Patchwork Wrapping in Water” at The 4th Asian Biomaterials Congress (Hong Kong, China).
http://www.abmc4.ust.hk/invitation.html

Presentation on “Adhesion Technology ~Development of Nanobiomaterials with Ubiquitous Adhesion Properties in Water~” at Bio tech 2013 (at Tokyo Big Sight, Tokyo, Japan).
http://may2013.tems-system.com/exhiSearch/BIO/jp/ExhiList#ADBI

Presentation on “Fragmentation of Biocompatible Polymer Nanosheets and Their Patchwork Coating” at The 93th Annual Meeting on Japan Chemical Society (at Ritsumeikan University Biwako-Kusatsu Campus, Shiga, Japan).
http://www.csj.jp/nenkai/93haru/index.html

Presentation on “Development of Innovative Nanobiomaterials and Their Biomedical Applications” at The 3rd Symposium for Tenure Track Program (at Tokai University Takanawa Campus, Tokyo, Japan).

Presentation on “Fragmentation of Biocompatible Polymer Nanosheets and Their Patchwork Wrapping in Water for Biomedical Applications” at The 9th SPSJ International Polymer Conference (IPC2012) (at Kobe International Conference Center, Kobe, Japan).
http://www.spsj.or.jp/IPC2012.html

Invited lecture on “Fabrication of nanobiomaterials and their medical applications ~polymer nanosheets and nanoparticles~” at 54th Shohoku area forum (at Tokai University Shonan Campus, Hiratsuka, Kanagawa)

Invited lecture on “Freestanding polymer nanosheets ~Challenge for novel biomedical applications~” at FY2012 The Web Handling Technical Study Group (at Tokai University Yamanakako seminar house, Yamanakako, Yamanashi)
http://www.ctiweb.co.jp/wht/

Invited lecture on “Free-standing nanosheets ~Challenge for biomedical applications~” at The 8th Workshop in the Institute of Medical Sciences, Tokai University (Yugawara, Kanagawa). (MVP Award)

Presentation on “Fragmentation of biodegradable polymer nanosheets and their patchwork dressing for burn wounds” at 61th Symposium on Macromolecules (at Nagoya Institute of Technology, Nagoya, Aichi)
http://www.spsj.or.jp/tohron.html

Presentation on “Fragmentation of biodegradable polymer nanosheets and their patchwork adsorption ~Biomedical application for novel wound dressing for burn~ ” at 7th Sagami Silicon-based materials forum (at Sagami Chemical Research Institute, Ayase, Kanagawa)
http://www.sagami.or.jp

Invited lecture on “Research abroad and start-up of laboratory” at FY2012 Seminar for research group of Biomolecular Assembly (Kamogawa, Chiba)

Presentation on “Fabrication of innovative nanobiomaterials and their medical applications” at FY2012 Tenure Track researcher Arrival Seminar (at Tokai University Shonan Campus, Hiratsuka, Kanagawa).
http://www.u-tokai.ac.jp/tuiist/tuiist/event.html

Presentation on “Does platelet-platelet membrane fusion occur?” at German-Japanese Joint Symposium for Diamond Researchers on Sustainability Life Science Innovation and Biomedical Research (Bonn, Germany).

Presentation on “A few immobilized ligands are sufficient for platelet spreading by thrombin” at Symposium between University of Bonn and Bayer Schering Pharma (Bonn, Germany).

Presentation on “Development of liposome-based platelet substitutes amplified by releasing adenosine diphosphate in the platelet aggregates” at Joint Symposium between Waseda University and the University of Bonn (Bonn, Germany).

Presentation on “Development of liposome-based platelet substitutes having an excellent hemostatic ability amplified by releasing adenosine 5’-diphosphate in the platelet aggregates” at The 11th Liposome Research Days International Conference (Yokohama, Japan). (Young Investigator Award)

Presentation on “Hemostatic effects of polymerized albumin particles carrying fibrinogen γ-chain dodecapeptide as platelet substitutes in vitro and in vivo” at The 10th International Symposium on Blood Substitutes (Providence, USA).

FY2013-14 Grant-in-aid for Young Scientists (B) from the Japan Society for the Promotion of Science.

FY2012 Grants-in-aid for Young Researchers from The Noguchi Institute
http://www.noguchi.or.jp/subsidy.php

FY2012-13 Grants-in-aid for Research Activity Start-up from the Japan Society for the Promotion of Science.

09.2010. - 03.2012. JSPS Postdoctoral Fellowships for Research Abroad

02.2010. - 08.2010. Alexander von Humboldt Fellowship for Postdoctoral Researchers

04.2005. - 03.2007. JSPS Research Fellowships for Young Scientists